Standings | Playoff brackets | Weekly rankings
| Season | Date | Away Team | Away Score | Home Team | Home Score | Notes | Source |
|---|---|---|---|---|---|---|---|
| 2010 | Friday, August 27, 2010 | Cheyenne Central | 9 | Natrona | 31 | CST | |
| 2010 | Friday, August 27, 2010 | Evanston | 44 | Campbell County | 21 | CST | |
| 2010 | Friday, August 27, 2010 | Green River | 30 | Cheyenne East | 33 | CST | |
| 2010 | Friday, August 27, 2010 | Laramie | 28 | Rock Springs | 47 | CST | |
| 2010 | Friday, August 27, 2010 | Sheridan | 35 | Kelly Walsh | 0 | CST | |
| 2010 | Friday, August 27, 2010 | Lovell | 7 | Thermopolis | 27 | CST | |
| 2010 | Friday, August 27, 2010 | Greybull | 40 | Riverside | 7 | BRR | |
| 2010 | Friday, August 27, 2010 | Lyman | 18 | Altamont (UT) | 21 | SLT | |
| 2010 | Friday, August 27, 2010 | Newcastle | 12 | Custer (SD) | 15 | CST | |
| 2010 | Friday, August 27, 2010 | Rich County (UT) | 33 | Mountain View | 0 | SLT | |
| 2010 | Saturday, August 28, 2010 | Jackson | 6 | Riverton | 49 | CST | |
| 2010 | Saturday, August 28, 2010 | Hulett | 20 | Midwest | 67 | MHS | |
| 2010 | Saturday, August 28, 2010 | Southeast | 16 | Cheyenne East JV | 20 | SHS | |
| 2010 | Saturday, August 28, 2010 | Wind River | 0 | Big Piney | 25 | CST | |
| 2010 | Saturday, August 28, 2010 | Cody | 12 | Laurel (MT) | 21 | BG | |
| 2010 | Saturday, August 28, 2010 | Powell | Miles City (MT) | canceled | BG | ||
| 2010 | Friday, September 3, 2010 | Cheyenne East | 20 | Sheridan | 46 | CST | |
| 2010 | Friday, September 3, 2010 | Campbell County | 52 | Laramie | 3 | CST | |
| 2010 | Friday, September 3, 2010 | Green River | 7 | Kelly Walsh | 21 | CST | |
| 2010 | Friday, September 3, 2010 | Natrona | 34 | Evanston | 10 | CST | |
| 2010 | Friday, September 3, 2010 | Rock Springs | 27 | Cheyenne Central | 41 | CST | |
| 2010 | Friday, September 3, 2010 | Lander | 47 | Rawlins | 7 | CST | |
| 2010 | Friday, September 3, 2010 | Riverton | 10 | Powell | 13 | CST | |
| 2010 | Friday, September 3, 2010 | Worland | 0 | Buffalo | 41 | CST | |
| 2010 | Friday, September 3, 2010 | Big Horn | 37 | Greybull | 14 | CST | |
| 2010 | Friday, September 3, 2010 | Kemmerer | 6 | Glenrock | 20 | BG | |
| 2010 | Friday, September 3, 2010 | Lovell | 21 | Wright | 20 | CST | |
| 2010 | Friday, September 3, 2010 | Thermopolis | 45 | Lyman | 30 | BG | |
| 2010 | Friday, September 3, 2010 | Burlington | 7 | Big Piney | 31 | BG | |
| 2010 | Friday, September 3, 2010 | Dubois | 48 | Upton | 0 | at Casper-NCHS | CST |
| 2010 | Friday, September 3, 2010 | Lingle | 33 | Saratoga | 6 | CST | |
| 2010 | Friday, September 3, 2010 | Normative Services | 0 | Rocky Mountain | 72 | BG | |
| 2010 | Friday, September 3, 2010 | Shoshoni | 7 | Pine Bluffs | 46 | BG | |
| 2010 | Friday, September 3, 2010 | Kaycee | 44 | Snake River | 68 | CST | |
| 2010 | Friday, September 3, 2010 | Meeteetse | 38 | Farson | 20 | CST | |
| 2010 | Friday, September 3, 2010 | Ten Sleep | 32 | Hanna | 34 | BG | |
| 2010 | Friday, September 3, 2010 | Lusk | 26 | Burns | 20 | CST | |
| 2010 | Friday, September 3, 2010 | Mountain View | 8 | Cokeville | 32 | BG | |
| 2010 | Friday, September 3, 2010 | Newcastle | 7 | Southeast | 27 | CST/TT | |
| 2010 | Friday, September 3, 2010 | Riverside | 23 | Pinedale | 20 | CST | |
| 2010 | Friday, September 3, 2010 | Sundance | 0 | Moorcroft | 6 | BG | |
| 2010 | Friday, September 3, 2010 | Wyoming Indian | 32 | Wind River | 47 | CST | |
| 2010 | Friday, September 3, 2010 | Belle Fourche (SD) | 6 | Douglas | 38 | CST | |
| 2010 | Friday, September 3, 2010 | Cody | 26 | Hardin (MT) | 7 | CST | |
| 2010 | Friday, September 3, 2010 | Jackson | 18 | Teton (ID) | 24 | CST | |
| 2010 | Friday, September 3, 2010 | Sidney (NE) | 7 | Wheatland | 38 | CST | |
| 2010 | Friday, September 3, 2010 | Snake River (ID) | 21 | Star Valley | 49 | CST | |
| 2010 | Friday, September 3, 2010 | Torrington | 13 | Chadron (NE) | 16 | CST | |
| 2010 | Friday, September 3, 2010 | Tongue River | 20 | Natrona sophs | 13 | SP | |
| 2010 | Saturday, September 4, 2010 | Midwest | 62 | Guernsey-Sunrise | 34 | CST | |
| 2010 | Thursday, September 9, 2010 | Wind River | 34 | Shoshoni | 6 | CST | |
| 2010 | Friday, September 10, 2010 | Cheyenne Central | 24 | Evanston | 47 | CST | |
| 2010 | Friday, September 10, 2010 | Campbell County | 42 | Rock Springs | 13 | CST | |
| 2010 | Friday, September 10, 2010 | Kelly Walsh | 25 | Cheyenne East | 49 | CST | |
| 2010 | Friday, September 10, 2010 | Laramie | 0 | Natrona | 52 | CST | |
| 2010 | Friday, September 10, 2010 | Sheridan | 10 | Green River | 7 | CST | |
| 2010 | Friday, September 10, 2010 | Buffalo | 41 | Lander | 6 | CST | |
| 2010 | Friday, September 10, 2010 | Douglas | 70 | Jackson | 14 | CST | |
| 2010 | Friday, September 10, 2010 | Rawlins | 0 | Cody | 51 | CST | |
| 2010 | Friday, September 10, 2010 | Star Valley | 6 | Riverton | 28 | CST | |
| 2010 | Friday, September 10, 2010 | Torrington | 19 | Worland | 7 | CST | |
| 2010 | Friday, September 10, 2010 | Wheatland | 16 | Powell | 23 | CST | |
| 2010 | Friday, September 10, 2010 | Big Piney | 51 | Wyoming Indian | 6 | CST | |
| 2010 | Friday, September 10, 2010 | Burns | 14 | Big Horn | 45 | CST | |
| 2010 | Friday, September 10, 2010 | Glenrock | 26 | Tongue River | 20 | CST | |
| 2010 | Friday, September 10, 2010 | Greybull | 28 | Mountain View | 13 | CST | |
| 2010 | Friday, September 10, 2010 | Lyman | 41 | Kemmerer | 6 | CST | |
| 2010 | Friday, September 10, 2010 | Moorcroft | 6 | Newcastle | 36 | CST | |
| 2010 | Friday, September 10, 2010 | Pinedale | 6 | Lovell | 27 | CST | |
| 2010 | Friday, September 10, 2010 | Wright | 13 | Thermopolis | 53 | CST | |
| 2010 | Friday, September 10, 2010 | Cokeville | 61 | Riverside | 6 | CST | |
| 2010 | Friday, September 10, 2010 | Pine Bluffs | 57 | Normative Services | 0 | CST | |
| 2010 | Friday, September 10, 2010 | Rocky Mountain | 12 | Dubois | 13 | CST | |
| 2010 | Friday, September 10, 2010 | Saratoga | 7 | Burlington | 12 | CST | |
| 2010 | Friday, September 10, 2010 | Southeast | 13 | Sundance | 14 | CST | |
| 2010 | Friday, September 10, 2010 | Upton | 0 | Lingle | 55 | CST | |
| 2010 | Friday, September 10, 2010 | Farson | 6 | Hanna | 58 | CST | |
| 2010 | Friday, September 10, 2010 | Kaycee | 48 | Midwest | 38 | CST | |
| 2010 | Saturday, September 11, 2010 | Meeteetse | 39 | Ten Sleep | 79 | WHSAA | |
| 2010 | Saturday, September 11, 2010 | Snake River | 59 | Guernsey-Sunrise | 6 | WHSAA | |
| 2010 | Saturday, September 11, 2010 | Hulett | 39 | Kaycee JV | 7 | KHS | |
| 2010 | Thursday, September 16, 2010 | Lingle | 37 | Natrona sophs | 39 | CST | |
| 2010 | Friday, September 17, 2010 | Cheyenne Central | 56 | Laramie | 7 | CST | |
| 2010 | Friday, September 17, 2010 | Cheyenne East | 14 | Campbell County | 42 | CST | |
| 2010 | Friday, September 17, 2010 | Evanston | 30 | Green River | 10 | CST | |
| 2010 | Friday, September 17, 2010 | Natrona | 45 | Kelly Walsh | 0 | CST | |
| 2010 | Friday, September 17, 2010 | Rock Springs | 6 | Sheridan | 15 | CST | |
| 2010 | Friday, September 17, 2010 | Cody | 47 | Torrington | 0 | CST | |
| 2010 | Friday, September 17, 2010 | Douglas | 40 | Star Valley | 6 | at Riverton | CST |
| 2010 | Friday, September 17, 2010 | Jackson | 13 | Rawlins | 7 | CST | |
| 2010 | Friday, September 17, 2010 | Powell | 0 | Buffalo | 36 | CST | |
| 2010 | Friday, September 17, 2010 | Riverton | 21 | Lander | 20 | CST | |
| 2010 | Friday, September 17, 2010 | Worland | 14 | Wheatland | 35 | CST | |
| 2010 | Friday, September 17, 2010 | Big Horn | 32 | Wright | 6 | CST | |
| 2010 | Friday, September 17, 2010 | Kemmerer | 0 | Pinedale | 24 | CST | |
| 2010 | Friday, September 17, 2010 | Lovell | 21 | Lyman | 27 | OT | CST |
| 2010 | Friday, September 17, 2010 | Mountain View | 21 | Big Piney | 18 | CST | |
| 2010 | Friday, September 17, 2010 | Newcastle | 10 | Burns | 6 | CST | |
| 2010 | Friday, September 17, 2010 | Thermopolis | 42 | Glenrock | 16 | CST | |
| 2010 | Friday, September 17, 2010 | Tongue River | 21 | Moorcroft | 0 | CST | |
| 2010 | Friday, September 17, 2010 | Wyoming Indian | 6 | Greybull | 56 | CST | |
| 2010 | Friday, September 17, 2010 | Dubois | 27 | Wind River | 25 | CST | |
| 2010 | Friday, September 17, 2010 | Normative Services | 12 | Upton | 25 | CST | |
| 2010 | Friday, September 17, 2010 | Riverside | 13 | Rocky Mountain | 24 | CST | |
| 2010 | Friday, September 17, 2010 | Saratoga | 0 | Cokeville | 60 | CST | |
| 2010 | Friday, September 17, 2010 | Shoshoni | 13 | Burlington | 39 | CST | |
| 2010 | Friday, September 17, 2010 | Southeast | 6 | Lusk | 46 | CST | |
| 2010 | Friday, September 17, 2010 | Sundance | 0 | Pine Bluffs | 42 | CST | |
| 2010 | Friday, September 17, 2010 | Farson | 0 | Snake River | 79 | CST | |
| 2010 | Saturday, September 18, 2010 | Guernsey-Sunrise | 19 | Meeteetse | 48 | WHSAA | |
| 2010 | Saturday, September 18, 2010 | Hanna | 33 | Kaycee | 47 | WHSAA | |
| 2010 | Saturday, September 18, 2010 | Ten Sleep | 39 | Midwest | 26 | WHSAA | |
| 2010 | Thursday, September 23, 2010 | Kaycee JV | 18 | Hulett | 53 | HHS | |
| 2010 | Friday, September 24, 2010 | Cheyenne East | 22 | Cheyenne Central | 38 | CST | |
| 2010 | Friday, September 24, 2010 | Campbell County | 27 | Sheridan | 24 | OT | CST |
| 2010 | Friday, September 24, 2010 | Green River | 12 | Natrona | 51 | CST | |
| 2010 | Friday, September 24, 2010 | Kelly Walsh | 24 | Rock Springs | 21 | CST | |
| 2010 | Friday, September 24, 2010 | Laramie | 16 | Evanston | 42 | CST | |
| 2010 | Friday, September 24, 2010 | Buffalo | 7 | Douglas | 22 | CST | |
| 2010 | Friday, September 24, 2010 | Lander | 0 | Cody | 31 | CST | |
| 2010 | Friday, September 24, 2010 | Powell | 56 | Jackson | 0 | CST | |
| 2010 | Friday, September 24, 2010 | Rawlins | 7 | Riverton | 49 | CST | |
| 2010 | Friday, September 24, 2010 | Wheatland | 48 | Torrington | 18 | CST | |
| 2010 | Friday, September 24, 2010 | Worland | 13 | Star Valley | 34 | CST | |
| 2010 | Friday, September 24, 2010 | Burns | 7 | Tongue River | 6 | CST | |
| 2010 | Friday, September 24, 2010 | Glenrock | 0 | Big Horn | 46 | at NSI | CST |
| 2010 | Friday, September 24, 2010 | Greybull | 46 | Pinedale | 10 | CST | |
| 2010 | Friday, September 24, 2010 | Lyman | 27 | Big Piney | 20 | CST | |
| 2010 | Friday, September 24, 2010 | Moorcroft | 14 | Thermopolis | 42 | CST | |
| 2010 | Friday, September 24, 2010 | Mountain View | 6 | Lovell | 20 | CST | |
| 2010 | Friday, September 24, 2010 | Wright | 28 | Newcastle | 21 | OT | CST |
| 2010 | Friday, September 24, 2010 | Burlington | 40 | Riverside | 12 | CST | |
| 2010 | Friday, September 24, 2010 | Dubois | 44 | Saratoga | 12 | CST | |
| 2010 | Friday, September 24, 2010 | Lusk | 52 | Lingle | 12 | CST | |
| 2010 | Friday, September 24, 2010 | Pine Bluffs | 26 | Southeast | 33 | OT | CST |
| 2010 | Friday, September 24, 2010 | Upton | 6 | Sundance | 56 | CST | |
| 2010 | Friday, September 24, 2010 | Wind River | 6 | Rocky Mountain | 42 | CST | |
| 2010 | Friday, September 24, 2010 | Cokeville | 57 | Shoshoni | 0 | CST | |
| 2010 | Saturday, September 25, 2010 | Wyoming Indian | 6 | Kemmerer | 53 | CST | |
| 2010 | Saturday, September 25, 2010 | Hanna | 64 | Guernsey-Sunrise | 24 | CST | |
| 2010 | Saturday, September 25, 2010 | Kaycee | 62 | Ten Sleep | 63 | CST | |
| 2010 | Saturday, September 25, 2010 | Midwest | 66 | Farson | 6 | CST | |
| 2010 | Saturday, September 25, 2010 | Snake River | 58 | Meeteetse | 12 | CST | |
| 2010 | Friday, October 1, 2010 | Evanston | 28 | Kelly Walsh | 10 | CST | |
| 2010 | Friday, October 1, 2010 | Cheyenne Central | 23 | Campbell County | 28 | CST | |
| 2010 | Friday, October 1, 2010 | Natrona | 53 | Cheyenne East | 3 | CST | |
| 2010 | Friday, October 1, 2010 | Rock Springs | 21 | Green River | 30 | CST | |
| 2010 | Friday, October 1, 2010 | Sheridan | 35 | Laramie | 0 | CST | |
| 2010 | Friday, October 1, 2010 | Buffalo | 49 | Riverton | 22 | CST | |
| 2010 | Friday, October 1, 2010 | Douglas | 21 | Wheatland | 13 | CST | |
| 2010 | Friday, October 1, 2010 | Jackson | 7 | Cody | 69 | CST | |
| 2010 | Friday, October 1, 2010 | Lander | 14 | Worland | 7 | CST | |
| 2010 | Friday, October 1, 2010 | Star Valley | 19 | Powell | 24 | CST | |
| 2010 | Friday, October 1, 2010 | Torrington | 38 | Rawlins | 14 | CST | |
| 2010 | Friday, October 1, 2010 | Big Piney | 32 | Kemmerer | 13 | CST | |
| 2010 | Friday, October 1, 2010 | Glenrock | 6 | Newcastle | 7 | CST | |
| 2010 | Friday, October 1, 2010 | Greybull | 6 | Lovell | 7 | CST | |
| 2010 | Friday, October 1, 2010 | Lyman | 49 | Wyoming Indian | 32 | CST | |
| 2010 | Friday, October 1, 2010 | Moorcroft | 0 | Burns | 48 | CST | |
| 2010 | Friday, October 1, 2010 | Pinedale | 20 | Mountain View | 0 | CST | |
| 2010 | Friday, October 1, 2010 | Thermopolis | 7 | Big Horn | 42 | at Sheridan | CST |
| 2010 | Friday, October 1, 2010 | Tongue River | 13 | Wright | 33 | CST | |
| 2010 | Friday, October 1, 2010 | Burlington | 8 | Dubois | 26 | CST | |
| 2010 | Friday, October 1, 2010 | Pine Bluffs | 7 | Lusk | 52 | CST | |
| 2010 | Friday, October 1, 2010 | Rocky Mountain | 6 | Cokeville | 47 | CST | |
| 2010 | Friday, October 1, 2010 | Saratoga | 10 | Wind River | 20 | CST | |
| 2010 | Friday, October 1, 2010 | Shoshoni | 13 | Riverside | 26 | CST | |
| 2010 | Friday, October 1, 2010 | Sundance | 32 | Lingle | 46 | CST | |
| 2010 | Friday, October 1, 2010 | Hulett | 34 | Upton | 38 | six-man | CST |
| 2010 | Friday, October 1, 2010 | Meeteetse | 14 | Kaycee | 81 | CST | |
| 2010 | Friday, October 1, 2010 | Midwest | 37 | Hanna | 45 | CST | |
| 2010 | Saturday, October 2, 2010 | Normative Services | 0 | Southeast | 56 | at Casper-NCHS | CST |
| 2010 | Saturday, October 2, 2010 | Farson | 6 | Guernsey-Sunrise | 59 | CST | |
| 2010 | Saturday, October 2, 2010 | Ten Sleep | 13 | Snake River | 52 | CST | |
| 2010 | Monday, October 4, 2010 | Moorcroft JV | 27 | Hulett | 20 | HHS | |
| 2010 | Friday, October 8, 2010 | Cheyenne East | 20 | Rock Springs | 37 | CST | |
| 2010 | Friday, October 8, 2010 | Evanston | 23 | Sheridan | 45 | CST | |
| 2010 | Friday, October 8, 2010 | Campbell County | 32 | Natrona | 47 | CST | |
| 2010 | Friday, October 8, 2010 | Green River | 31 | Cheyenne Central | 30 | CST | |
| 2010 | Friday, October 8, 2010 | Kelly Walsh | 10 | Laramie | 7 | CST | |
| 2010 | Friday, October 8, 2010 | Cody | 41 | Star Valley | 21 | CST | |
| 2010 | Friday, October 8, 2010 | Douglas | 64 | Rawlins | 0 | CST | |
| 2010 | Friday, October 8, 2010 | Jackson | 7 | Lander | 35 | CST | |
| 2010 | Friday, October 8, 2010 | Powell | 18 | Worland | 21 | CST | |
| 2010 | Friday, October 8, 2010 | Riverton | 21 | Torrington | 12 | CST | |
| 2010 | Friday, October 8, 2010 | Wheatland | 7 | Buffalo | 63 | CST | |
| 2010 | Friday, October 8, 2010 | Big Horn | 58 | Moorcroft | 6 | CST | |
| 2010 | Friday, October 8, 2010 | Big Piney | 15 | Pinedale | 7 | CST | |
| 2010 | Friday, October 8, 2010 | Burns | 20 | Thermopolis | 55 | CST | |
| 2010 | Friday, October 8, 2010 | Kemmerer | 14 | Greybull | 55 | CST | |
| 2010 | Friday, October 8, 2010 | Lovell | 59 | Wyoming Indian | 0 | CST | |
| 2010 | Friday, October 8, 2010 | Mountain View | 0 | Lyman | 25 | CST | |
| 2010 | Friday, October 8, 2010 | Newcastle | 8 | Tongue River | 6 | CST | |
| 2010 | Friday, October 8, 2010 | Wright | 20 | Glenrock | 16 | CST | |
| 2010 | Friday, October 8, 2010 | Dubois | 6 | Cokeville | 48 | CST | |
| 2010 | Friday, October 8, 2010 | Lingle | 60 | Normative Services | 6 | CST | |
| 2010 | Friday, October 8, 2010 | Riverside | 16 | Saratoga | 14 | CST | |
| 2010 | Friday, October 8, 2010 | Rocky Mountain | 35 | Shoshoni | 0 | CST | |
| 2010 | Friday, October 8, 2010 | Sundance | 0 | Lusk | 53 | CST | |
| 2010 | Friday, October 8, 2010 | Upton | 6 | Pine Bluffs | 53 | CST | |
| 2010 | Friday, October 8, 2010 | Wind River | 7 | Burlington | 15 | CST | |
| 2010 | Friday, October 8, 2010 | Meeteetse | 6 | Midwest | 64 | CST | |
| 2010 | Friday, October 8, 2010 | Snake River | 50 | Hanna | 34 | CST | |
| 2010 | Saturday, October 9, 2010 | Guernsey-Sunrise | 56 | Ten Sleep | 93 | CST | |
| 2010 | Saturday, October 9, 2010 | Kaycee | 83 | Farson | 13 | CST | |
| 2010 | Thursday, October 14, 2010 | Pinedale | 6 | Lyman | 46 | CST | |
| 2010 | Thursday, October 14, 2010 | Cokeville | 47 | Wind River | 0 | CST | |
| 2010 | Friday, October 15, 2010 | Cheyenne East | 0 | Evanston | 42 | CST | |
| 2010 | Friday, October 15, 2010 | Kelly Walsh | 23 | Campbell County | 56 | CST | |
| 2010 | Friday, October 15, 2010 | Laramie | 35 | Green River | 26 | CST | |
| 2010 | Friday, October 15, 2010 | Rock Springs | 14 | Natrona | 43 | CST | |
| 2010 | Friday, October 15, 2010 | Sheridan | 21 | Cheyenne Central | 28 | CST | |
| 2010 | Friday, October 15, 2010 | Buffalo | 60 | Torrington | 10 | CST | |
| 2010 | Friday, October 15, 2010 | Powell | 14 | Cody | 27 | CST | |
| 2010 | Friday, October 15, 2010 | Rawlins | 0 | Wheatland | 50 | CST | |
| 2010 | Friday, October 15, 2010 | Riverton | 9 | Douglas | 27 | CST | |
| 2010 | Friday, October 15, 2010 | Star Valley | 20 | Lander | 27 | CST | |
| 2010 | Friday, October 15, 2010 | Worland | 24 | Jackson | 15 | CST | |
| 2010 | Friday, October 15, 2010 | Big Horn | 37 | Tongue River | 8 | CST | |
| 2010 | Friday, October 15, 2010 | Burns | 42 | Glenrock | 14 | CST | |
| 2010 | Friday, October 15, 2010 | Greybull | 41 | Big Piney | 12 | CST | |
| 2010 | Friday, October 15, 2010 | Lovell | 34 | Kemmerer | 7 | CST | |
| 2010 | Friday, October 15, 2010 | Moorcroft | 0 | Wright | 32 | CST | |
| 2010 | Friday, October 15, 2010 | Thermopolis | 47 | Newcastle | 34 | CST | |
| 2010 | Friday, October 15, 2010 | Wyoming Indian | 0 | Mountain View | 34 | CST | |
| 2010 | Friday, October 15, 2010 | Burlington | 6 | Rocky Mountain | 27 | CST | |
| 2010 | Friday, October 15, 2010 | Lingle | 44 | Pine Bluffs | 36 | CST | |
| 2010 | Friday, October 15, 2010 | Lusk | 62 | Normative Services | 0 | CST | |
| 2010 | Friday, October 15, 2010 | Riverside | 24 | Dubois | 67 | CST | |
| 2010 | Friday, October 15, 2010 | Saratoga | 28 | Shoshoni | 8 | CST | |
| 2010 | Friday, October 15, 2010 | Upton | 6 | Southeast | 58 | CST | |
| 2010 | Friday, October 15, 2010 | Hulett | 20 | Sundance | 85 | six-man | HHS |
| 2010 | Friday, October 15, 2010 | Farson | 0 | Ten Sleep | 70 | CST | |
| 2010 | Friday, October 15, 2010 | Hanna | 56 | Meeteetse | 20 | CST | |
| 2010 | Saturday, October 16, 2010 | Guernsey-Sunrise | 18 | Kaycee | 87 | CST | |
| 2010 | Saturday, October 16, 2010 | Midwest | 19 | Snake River | 68 | CST | |
| 2010 | Thursday, October 21, 2010 | Shoshoni | 0 | Dubois | 52 | CST | |
| 2010 | Friday, October 22, 2010 | Cheyenne Central | 17 | Kelly Walsh | 10 | CST | |
| 2010 | Friday, October 22, 2010 | Evanston | 35 | Rock Springs | 28 | CST | |
| 2010 | Friday, October 22, 2010 | Green River | 29 | Campbell County | 70 | CST | |
| 2010 | Friday, October 22, 2010 | Laramie | 21 | Cheyenne East | 48 | CST | |
| 2010 | Friday, October 22, 2010 | Natrona | 17 | Sheridan | 18 | CST | |
| 2010 | Friday, October 22, 2010 | Cody | 58 | Worland | 7 | CST | |
| 2010 | Friday, October 22, 2010 | Lander | 7 | Powell | 21 | CST | |
| 2010 | Friday, October 22, 2010 | Rawlins | 0 | Buffalo | 68 | CST | |
| 2010 | Friday, October 22, 2010 | Star Valley | 41 | Jackson | 6 | CST | |
| 2010 | Friday, October 22, 2010 | Torrington | 8 | Douglas | 45 | CST | |
| 2010 | Friday, October 22, 2010 | Wheatland | 30 | Riverton | 41 | CST | |
| 2010 | Friday, October 22, 2010 | Big Piney | 7 | Lovell | 14 | CST | |
| 2010 | Friday, October 22, 2010 | Glenrock | 14 | Moorcroft | 20 | CST | |
| 2010 | Friday, October 22, 2010 | Kemmerer | 8 | Mountain View | 28 | CST | |
| 2010 | Friday, October 22, 2010 | Lyman | 0 | Greybull | 24 | CST | |
| 2010 | Friday, October 22, 2010 | Newcastle | 13 | Big Horn | 35 | CST | |
| 2010 | Friday, October 22, 2010 | Pinedale | 39 | Wyoming Indian | 14 | CST | |
| 2010 | Friday, October 22, 2010 | Tongue River | 17 | Thermopolis | 42 | CST | |
| 2010 | Friday, October 22, 2010 | Wright | 18 | Burns | 25 | CST | |
| 2010 | Friday, October 22, 2010 | Cokeville | Burlington | Cokeville win by forfeit | CST | ||
| 2010 | Friday, October 22, 2010 | Lusk | 65 | Upton | 0 | CST | |
| 2010 | Friday, October 22, 2010 | Normative Services | 0 | Sundance | 51 | CST | |
| 2010 | Friday, October 22, 2010 | Rocky Mountain | 28 | Saratoga | 12 | CST | |
| 2010 | Friday, October 22, 2010 | Southeast | 27 | Lingle | 22 | WHSAA | |
| 2010 | Friday, October 22, 2010 | Wind River | 25 | Riverside | 26 | CST | |
| 2010 | Friday, October 22, 2010 | Guernsey-Sunrise | 19 | Sioux County (NE) | 58 | CST | |
| 2010 | Friday, October 29, 2010 | Green River | 0 | Natrona | 45 | 4A QF | CST |
| 2010 | Friday, October 29, 2010 | Cheyenne Central | 21 | Campbell County | 38 | 4A QF | CST |
| 2010 | Friday, October 29, 2010 | Cheyenne East | 30 | Evanston | 20 | 4A QF | CST |
| 2010 | Friday, October 29, 2010 | Kelly Walsh | 3 | Sheridan | 10 | 4A QF | CST |
| 2010 | Friday, October 29, 2010 | Star Valley | 18 | Douglas | 54 | 3A QF | CST |
| 2010 | Friday, October 29, 2010 | Riverton | 10 | Powell | 7 | 3A QF | CST |
| 2010 | Friday, October 29, 2010 | Lander | 7 | Buffalo | 51 | 3A QF | CST |
| 2010 | Friday, October 29, 2010 | Wheatland | 19 | Cody | 49 | 3A QF | CST |
| 2010 | Friday, October 29, 2010 | Big Piney | 6 | Big Horn | 62 | 2A QF | CST |
| 2010 | Friday, October 29, 2010 | Newcastle | 14 | Greybull | 30 | 2A QF | CST |
| 2010 | Friday, October 29, 2010 | Lyman | 0 | Thermopolis | 53 | 2A QF | CST |
| 2010 | Friday, October 29, 2010 | Burns | 0 | Lovell | 20 | 2A QF | CST |
| 2010 | Friday, October 29, 2010 | Burlington | 0 | Lusk | 47 | 1A-11 QF | CST |
| 2010 | Friday, October 29, 2010 | Lingle | 38 | Dubois | 18 | 1A-11 QF | CST |
| 2010 | Friday, October 29, 2010 | Rocky Mountain | 14 | Southeast | 15 | 1A-11 QF | CST |
| 2010 | Friday, October 29, 2010 | Pine Bluffs | 0 | Cokeville | 49 | 1A-11 QF | CST |
| 2010 | Friday, October 29, 2010 | Farson | 0 | Snake River | 64 | 1A-6 QF | CST |
| 2010 | Friday, October 29, 2010 | Midwest | 32 | Kaycee | 60 | 1A-6 QF | CST |
| 2010 | Friday, October 29, 2010 | Meeteetse | 38 | Ten Sleep | 93 | 1A-6 QF | CST |
| 2010 | Friday, October 29, 2010 | Guernsey-Sunrise | 0 | Hanna | 51 | 1A-6 QF | CST |
| 2010 | Friday, November 5, 2010 | Cheyenne East | 12 | Sheridan | 46 | 4A SF | CST |
| 2010 | Friday, November 5, 2010 | Buffalo | 24 | Cody | 21 | 3A SF-OT | CST |
| 2010 | Friday, November 5, 2010 | Riverton | 2 | Douglas | 23 | 3A SF | CST |
| 2010 | Friday, November 5, 2010 | Lingle | 15 | Lusk | 66 | 1A-11 SF | CST |
| 2010 | Saturday, November 6, 2010 | Campbell County | 10 | Natrona | 30 | 4A SF | CST |
| 2010 | Saturday, November 6, 2010 | Thermopolis | 39 | Lovell | 15 | 2A SF | CST |
| 2010 | Saturday, November 6, 2010 | Greybull | 7 | Big Horn | 37 | 2A SF | CST |
| 2010 | Saturday, November 6, 2010 | Southeast | 7 | Cokeville | 24 | 1A-11 SF | CST |
| 2010 | Saturday, November 6, 2010 | Kaycee | 12 | Snake River | 42 | 1A-6 SF | CST |
| 2010 | Saturday, November 6, 2010 | Ten Sleep | 32 | Hanna | 33 | 1A-6 SF | CST |
| 2010 | Friday, November 12, 2010 | Hanna | 12 | Snake River | 67 | 1A-6 Championship-at Laramie | CST |
| 2010 | Friday, November 12, 2010 | Buffalo | 14 | Douglas | 26 | 3A Championship-at Laramie | CST |
| 2010 | Saturday, November 13, 2010 | Thermopolis | 13 | Big Horn | 9 | 2A Championship-at Laramie | CST |
| 2010 | Saturday, November 13, 2010 | Lusk | 6 | Cokeville | 26 | 1A-11 Championship-at Laramie | CST |
| 2010 | Saturday, November 13, 2010 | Sheridan | 14 | Natrona | 34 | 4A Championship-at Laramie | CST |
| Season | Date | Away Team | Away Score | Home Team | Home Score | Notes | Source |