Standings | Playoff brackets | Weekly rankings
| Season | Date | Away Team | Away Score | Home Team | Home Score | Notes | Source |
|---|---|---|---|---|---|---|---|
| 2021 | Friday, August 27, 2021 | Kelly Walsh | 70 | Cheyenne South | 14 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Natrona | 22 | Cheyenne Central | 0 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Campbell County | 8 | Rock Springs | 56 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Sheridan | 57 | Laramie | 0 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Thunder Basin | 39 | Cheyenne East | 34 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Powell | 37 | Riverton | 7 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Glenrock | 21 | Natrona sophs | 14 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Wheatland | 36 | Rawlins | 0 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Big Piney | 13 | Bear Lake (ID) | 42 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Meeteetse | 32 | Bridger (MT) | 34 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Evanston | 14 | Ben Lomond (UT) | 13 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Gering (NE) | 14 | Torrington | 9 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Hot Springs (SD) | 23 | Newcastle | 0 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Teton (ID) | 20 | Jackson | 51 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Malad (ID) | 14 | Lyman | 22 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Star Valley | 22 | Summit Academy (UT) | 21 | WHSAA | |
| 2021 | Friday, August 27, 2021 | Burns | 6 | Yuma (CO) | 41 | WHSAA | |
| 2021 | Thursday, September 2, 2021 | Pine Bluffs | 30 | Riverside | 0 | WHSAA | |
| 2021 | Thursday, September 2, 2021 | Big Piney | 26 | Evanston JV | 6 | WHSAA | |
| 2021 | Thursday, September 2, 2021 | Lyman | 36 | Rawlins | 6 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Cheyenne Central | 13 | Kelly Walsh | 21 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Cheyenne East | 14 | Natrona | 13 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Cheyenne South | 0 | Sheridan | 56 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Laramie | 3 | Campbell County | 48 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Rock Springs | 33 | Thunder Basin | 17 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Cody | 57 | Riverton | 10 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Green River | 12 | Lander | 43 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Worland | 13 | Powell | 29 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Big Horn | 0 | Lovell | 20 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Glenrock | 44 | Pinedale | 0 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Thermopolis | Tongue River | Tongue River win by forfeit | WHSAA | ||
| 2021 | Friday, September 3, 2021 | Wheatland | 46 | Kemmerer | 6 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Lingle | Wind River | Wind River win by forfeit | WHSAA | ||
| 2021 | Friday, September 3, 2021 | Moorcroft | 20 | Greybull | 26 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Rocky Mountain | 21 | Wright | 7 | WHSAA | |
| 2021 | Friday, September 3, 2021 | St. Stephens | Lusk | Lusk win by forfeit | WHSAA | ||
| 2021 | Friday, September 3, 2021 | Southeast | 7 | Shoshoni | 40 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Wyoming Indian | 8 | Saratoga | 62 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Dubois | 68 | Kaycee | 7 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Encampment | 73 | Midwest | 13 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Farson | 65 | Guernsey-Sunrise | 24 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Hulett | 64 | Burlington | 58 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Buffalo | 38 | Newcastle | 0 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Evanston | 22 | Mountain View | 21 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Torrington | Douglas | Douglas win by forfeit | WHSAA | ||
| 2021 | Friday, September 3, 2021 | Bear Lake (ID) | 8 | Jackson | 20 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Cokeville | 31 | Rich County (UT) | 6 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Mitchell (NE) | Burns | Mitchell (NE) win by forfeit | WHSAA | ||
| 2021 | Friday, September 3, 2021 | Star Valley | 27 | Preston (ID) | 28 | WHSAA | |
| 2021 | Friday, September 3, 2021 | Upton-Sundance | 54 | Lead-Deadwood (SD) | 21 | WHSAA | |
| 2021 | Saturday, September 4, 2021 | Hanna | 0 | Snake River | 61 | WHSAA | |
| 2021 | Saturday, September 4, 2021 | Sheridan JV | 7 | Tongue River | 42 | WHSAA | |
| 2021 | Thursday, September 9, 2021 | Newcastle | 6 | Upton-Sundance | 28 | at Sundance | WHSAA |
| 2021 | Thursday, September 9, 2021 | Natrona JV | 25 | Hulett | 70 | WHSAA | |
| 2021 | Thursday, September 9, 2021 | Jackson | 20 | Pocatello (ID) | 46 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Campbell County | 21 | Cheyenne East | 27 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Kelly Walsh | 0 | Rock Springs | 52 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Natrona | 45 | Laramie | 0 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Sheridan | 31 | Cheyenne Central | 20 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Thunder Basin | 45 | Cheyenne South | 6 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Cody | 35 | Worland | 21 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Green River | 19 | Buffalo | 20 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Powell | 35 | Lander | 13 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Riverton | 13 | Evanston | 19 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Big Horn | 13 | Wheatland | 20 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Burns | 8 | Tongue River | 12 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Cokeville | 20 | Lyman | 30 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Kemmerer | 20 | Pinedale | 0 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Lovell | 20 | Mountain View | 7 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Torrington | 34 | Glenrock | 0 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Greybull | 6 | Wind River | 56 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Lusk | 8 | Pine Bluffs | 32 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Saratoga | 34 | Moorcroft | 6 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Shoshoni | 27 | Rocky Mountain | 10 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Southeast | 26 | Lingle | 6 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Wright | 53 | Wyoming Indian | 0 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Encampment | 24 | Snake River | 66 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Belle Fourche (SD) | 0 | Douglas | 51 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Rawlins | 7 | Moffat County (CO) | 42 | WHSAA | |
| 2021 | Friday, September 10, 2021 | Sugar-Salem (ID) | 22 | Star Valley | 6 | WHSAA | |
| 2021 | Saturday, September 11, 2021 | Riverside | 64 | St. Stephens | 28 | WHSAA | |
| 2021 | Saturday, September 11, 2021 | Burlington | 10 | Farson | 20 | WHSAA | |
| 2021 | Saturday, September 11, 2021 | Meeteetse | 51 | Kaycee | 6 | WHSAA | |
| 2021 | Saturday, September 11, 2021 | Cheyenne Central JV | Guernsey-Sunrise | Central JV win by forfeit | WHSAA | ||
| 2021 | Saturday, September 11, 2021 | Hanna | Cheyenne East sophs | canceled | WHSAA | ||
| 2021 | Saturday, September 11, 2021 | Midwest | 7 | Dubois | 86 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Cheyenne Central | 7 | Thunder Basin | 10 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Cheyenne East | 49 | Laramie | 8 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Cheyenne South | 15 | Campbell County | 67 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Kelly Walsh | 7 | Natrona | 42 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Rock Springs | 24 | Sheridan | 27 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Buffalo | 14 | Cody | 49 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Douglas | 0 | Powell | 17 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Lander | 14 | Evanston | 20 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Riverton | 17 | Jackson | 28 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Star Valley | 74 | Rawlins | 7 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Worland | 49 | Green River | 35 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Glenrock | 22 | Burns | 26 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Kemmerer | 14 | Thermopolis | 41 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Lyman | 34 | Lovell | 15 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Mountain View | 7 | Cokeville | 28 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Newcastle | 0 | Big Horn | 20 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Pinedale | 0 | Big Piney | 28 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Tongue River | 14 | Torrington | 42 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Upton-Sundance | 28 | Wheatland | 38 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Lingle | 7 | Wright | 20 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Moorcroft | 6 | Lusk | 50 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Pine Bluffs | 52 | Saratoga | 0 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Rocky Mountain | 19 | Riverside | 12 | WHSAA | |
| 2021 | Friday, September 17, 2021 | St. Stephens | 6 | Shoshoni | 72 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Wind River | 8 | Southeast | 6 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Wyoming Indian | 0 | Greybull | 50 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Snake River | 68 | Burlington | 16 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Hulett | 67 | Sheridan JV | 54 | WHSAA | |
| 2021 | Friday, September 17, 2021 | Sioux County (NE) | 42 | Guernsey-Sunrise | 44 | WHSAA | |
| 2021 | Saturday, September 18, 2021 | Dubois | 68 | Meeteetse | 80 | WHSAA | |
| 2021 | Saturday, September 18, 2021 | Farson | 30 | Encampment | 38 | WHSAA | |
| 2021 | Saturday, September 18, 2021 | Hanna | Natrona sophs | canceled | WHSAA | ||
| 2021 | Saturday, September 18, 2021 | Natrona sophs | 32 | Midwest | 75 | WHSAA | |
| 2021 | Thursday, September 23, 2021 | Big Piney | 26 | Lyman | 42 | WHSAA | |
| 2021 | Thursday, September 23, 2021 | Riverside | 58 | Wyoming Indian | 0 | WHSAA | |
| 2021 | Thursday, September 23, 2021 | Wind River | 0 | Shoshoni | 19 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Cheyenne South | 0 | Cheyenne Central | 38 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Laramie | 24 | Kelly Walsh | 34 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Natrona | 14 | Rock Springs | 17 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Sheridan | 21 | Cheyenne East | 24 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Thunder Basin | 61 | Campbell County | 15 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Evanston | 27 | Green River | 7 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Jackson | 28 | Star Valley | 22 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Lander | 17 | Worland | 24 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Powell | 14 | Cody | 38 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Rawlins | 6 | Buffalo | 48 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Riverton | 0 | Douglas | 49 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Burns | 8 | Big Horn | 30 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Cokeville | 36 | Pinedale | 0 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Lovell | 51 | Thermopolis | 15 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Mountain View | 20 | Kemmerer | 21 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Tongue River | 17 | Newcastle | 20 | OT | WHSAA |
| 2021 | Friday, September 24, 2021 | Torrington | 24 | Upton-Sundance | 14 | at Upton | WHSAA |
| 2021 | Friday, September 24, 2021 | Wheatland | 41 | Glenrock | 6 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Greybull | 20 | Rocky Mountain | 35 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Lusk | 46 | Lingle | 36 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Pine Bluffs | 52 | Southeast | 19 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Wright | 21 | Moorcroft | 6 | WHSAA | |
| 2021 | Friday, September 24, 2021 | Meeteetse | 74 | Burlington | 68 | WHSAA | |
| 2021 | Saturday, September 25, 2021 | Saratoga | St. Stephens | Saratoga win by forfeit | WHSAA | ||
| 2021 | Saturday, September 25, 2021 | Dubois | 0 | Snake River | 46 | WHSAA | |
| 2021 | Saturday, September 25, 2021 | Guernsey-Sunrise | 50 | Hanna | 13 | WHSAA | |
| 2021 | Saturday, September 25, 2021 | Kaycee | 24 | Hulett | 73 | WHSAA | |
| 2021 | Saturday, September 25, 2021 | Kelly Walsh sophs | 6 | Midwest | 51 | WHSAA | |
| 2021 | Saturday, September 25, 2021 | Natrona sophs | Encampment | canceled | WHSAA | ||
| 2021 | Friday, October 1, 2021 | Campbell County | 27 | Cheyenne Central | 24 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Cheyenne East | 56 | Cheyenne South | 7 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Kelly Walsh | 21 | Thunder Basin | 61 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Natrona | 0 | Sheridan | 27 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Rock Springs | 50 | Laramie | 16 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Buffalo | 42 | Riverton | 7 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Cody | 49 | Evanston | 14 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Douglas | 29 | Lander | 6 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Green River | 12 | Jackson | 53 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Powell | 13 | Star Valley | 29 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Rawlins | 7 | Worland | 49 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Big Horn | 35 | Torrington | 42 | 2OT | WHSAA |
| 2021 | Friday, October 1, 2021 | Big Piney | 6 | Lovell | 28 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Glenrock | 6 | Newcastle | 25 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Lyman | 51 | Kemmerer | 8 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Thermopolis | 12 | Cokeville | 46 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Wheatland | 14 | Burns | 18 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Lingle | 21 | Saratoga | 16 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Riverside | 12 | Wind River | 48 | WHSAA | |
| 2021 | Friday, October 1, 2021 | St. Stephens | Greybull | Greybull win by forfeit | WHSAA | ||
| 2021 | Friday, October 1, 2021 | Shoshoni | 25 | Pine Bluffs | 34 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Southeast | 54 | Moorcroft | 16 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Wright | 7 | Lusk | 54 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Burlington | 24 | Dubois | 69 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Encampment | 46 | Meeteetse | 42 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Hanna | 0 | Midwest | 50 | called at halftime | WHSAA |
| 2021 | Friday, October 1, 2021 | Hulett | 75 | Guernsey-Sunrise | 14 | WHSAA | |
| 2021 | Friday, October 1, 2021 | Kaycee | 24 | Farson | 40 | WHSAA | |
| 2021 | Saturday, October 2, 2021 | Upton-Sundance | 34 | Tongue River | 15 | WHSAA | |
| 2021 | Saturday, October 2, 2021 | Pinedale | 0 | Mountain View | 57 | WHSAA | |
| 2021 | Saturday, October 2, 2021 | Rocky Mountain | 54 | Wyoming Indian | 0 | WHSAA | |
| 2021 | Thursday, October 7, 2021 | Wind River | 76 | St. Stephens | 8 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Campbell County | 2 | Natrona | 35 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Cheyenne Central | 27 | Cheyenne East | 33 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Cheyenne South | 0 | Rock Springs | 65 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Kelly Walsh | 0 | Sheridan | 42 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Thunder Basin | 55 | Laramie | 22 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Douglas | Rawlins | Douglas win by forfeit | WHSAA | ||
| 2021 | Friday, October 8, 2021 | Green River | 0 | Powell | 48 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Jackson | 42 | Evanston | 7 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Riverton | 7 | Lander | 17 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Star Valley | 3 | Cody | 22 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Worland | 23 | Buffalo | 40 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Burns | 12 | Upton-Sundance | 21 | at Sundance | WHSAA |
| 2021 | Friday, October 8, 2021 | Glenrock | 0 | Big Horn | 26 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Kemmerer | 0 | Cokeville | 30 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Lovell | 49 | Pinedale | 12 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Lyman | 14 | Thermopolis | 6 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Mountain View | 7 | Big Piney | 27 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Newcastle | 22 | Torrington | 35 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Tongue River | 14 | Wheatland | 20 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Greybull | 12 | Riverside | 14 | OT | WHSAA |
| 2021 | Friday, October 8, 2021 | Lusk | 14 | Rocky Mountain | 21 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Moorcroft | 16 | Lingle | 53 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Pine Bluffs | 48 | Wright | 6 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Saratoga | 16 | Southeast | 48 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Wyoming Indian | 0 | Shoshoni | 67 | WHSAA | |
| 2021 | Friday, October 8, 2021 | Guernsey-Sunrise | 42 | Kaycee | 35 | WHSAA | |
| 2021 | Saturday, October 9, 2021 | Encampment | 58 | Hanna | 12 | WHSAA | |
| 2021 | Saturday, October 9, 2021 | Farson | 22 | Dubois | 59 | WHSAA | |
| 2021 | Saturday, October 9, 2021 | Meeteetse | 23 | Snake River | 29 | WHSAA | |
| 2021 | Saturday, October 9, 2021 | Midwest | 6 | Hulett | 65 | WHSAA | |
| 2021 | Thursday, October 14, 2021 | Evanston | 6 | Star Valley | 40 | WHSAA | |
| 2021 | Thursday, October 14, 2021 | Pinedale | 6 | Lyman | 58 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Cheyenne Central | 18 | Rock Springs | 42 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Cheyenne East | 40 | Kelly Walsh | 7 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Laramie | 42 | Cheyenne South | 19 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Natrona | 28 | Thunder Basin | 14 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Sheridan | 38 | Campbell County | 7 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Buffalo | 7 | Douglas | 41 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Cody | 47 | Green River | 20 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Lander | 30 | Rawlins | 0 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Powell | 17 | Jackson | 21 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Worland | 34 | Riverton | 20 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Cokeville | 21 | Big Piney | 28 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Kemmerer | 6 | Lovell | 55 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Newcastle | 10 | Burns | 6 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Thermopolis | 40 | Mountain View | 13 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Torrington | 21 | Wheatland | 12 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Upton-Sundance | 45 | Glenrock | 0 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Lingle | 6 | Pine Bluffs | 63 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Saratoga | 14 | Wright | 32 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Shoshoni | 54 | Greybull | 6 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Southeast | 32 | Lusk | 38 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Rocky Mountain | 41 | Wind River | 26 | WHSAA | |
| 2021 | Friday, October 15, 2021 | Kaycee | 19 | Midwest | 14 | WHSAA | |
| 2021 | Saturday, October 16, 2021 | Big Horn | 21 | Tongue River | 22 | WHSAA | |
| 2021 | Saturday, October 16, 2021 | Riverside | 16 | Moorcroft | 6 | WHSAA | |
| 2021 | Saturday, October 16, 2021 | Wyoming Indian | 0 | St. Stephens | 38 | WHSAA | |
| 2021 | Saturday, October 16, 2021 | Burlington | 64 | Guernsey-Sunrise | 22 | WHSAA | |
| 2021 | Saturday, October 16, 2021 | Dubois | 26 | Encampment | 61 | WHSAA | |
| 2021 | Saturday, October 16, 2021 | Farson | 22 | Meeteetse | 50 | WHSAA | |
| 2021 | Saturday, October 16, 2021 | Hanna | 0 | Hulett | 57 | at Midwest | WHSAA |
| 2021 | Saturday, October 16, 2021 | Snake River | 51 | Natrona sophs | 6 | WHSAA | |
| 2021 | Tuesday, October 19, 2021 | Thermopolis | 6 | Big Piney | 27 | WHSAA | |
| 2021 | Thursday, October 21, 2021 | Mountain View | 7 | Lyman | 40 | WHSAA | |
| 2021 | Thursday, October 21, 2021 | St. Stephens | 0 | Rocky Mountain | 80 | WHSAA | |
| 2021 | Thursday, October 21, 2021 | Shoshoni | 46 | Riverside | 12 | WHSAA | |
| 2021 | Thursday, October 21, 2021 | Wind River | 54 | Wyoming Indian | 0 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Campbell County | 33 | Kelly Walsh | 6 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Cheyenne South | 27 | Natrona | 51 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Laramie | 13 | Cheyenne Central | 58 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Rock Springs | 31 | Cheyenne East | 15 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Sheridan | 28 | Thunder Basin | 20 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Douglas | 16 | Worland | 7 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Evanston | 6 | Powell | 39 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Jackson | 15 | Cody | 21 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Lander | 22 | Buffalo | 12 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Rawlins | 14 | Riverton | 40 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Star Valley | 51 | Green River | 7 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Big Piney | 37 | Kemmerer | 20 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Burns | 6 | Torrington | 24 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Lovell | 21 | Cokeville | 6 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Pinedale | 20 | Thermopolis | 42 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Tongue River | 42 | Glenrock | 14 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Upton-Sundance | 40 | Big Horn | 14 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Wheatland | 40 | Newcastle | 38 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Greybull | 24 | Lingle | 31 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Lusk | 48 | Saratoga | 6 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Moorcroft | 0 | Pine Bluffs | 66 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Wright | 6 | Southeast | 40 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Encampment | 65 | Burlington | 40 | WHSAA | |
| 2021 | Friday, October 22, 2021 | Midwest | 44 | Guernsey-Sunrise | 18 | WHSAA | |
| 2021 | Saturday, October 23, 2021 | Dubois | 26 | Hulett | 40 | at Ten Sleep | WHSAA |
| 2021 | Saturday, October 23, 2021 | Kaycee | 53 | Hanna | 6 | WHSAA | |
| 2021 | Saturday, October 23, 2021 | Snake River | 29 | Farson | 12 | WHSAA | |
| 2021 | Friday, October 29, 2021 | Cheyenne Central | 14 | Sheridan | 48 | 4A QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Thunder Basin | 14 | Natrona | 17 | 4A QF-OT | WHSAA |
| 2021 | Friday, October 29, 2021 | Kelly Walsh | 21 | Rock Springs | 42 | 4A QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Campbell County | 12 | Cheyenne East | 31 | 4A QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Powell | 10 | Douglas | 14 | 3A QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Buffalo | 27 | Jackson | 75 | 3A QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Worland | 7 | Cody | 40 | 3A QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Star Valley | 50 | Lander | 20 | 3A QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Big Horn | 20 | Lyman | 42 | 2A QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Big Piney | 0 | Wheatland | 45 | 2A QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Cokeville | 14 | Torrington | 21 | 2A QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Upton-Sundance | 8 | Lovell | 21 | 2A QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Wright | 0 | Shoshoni | 55 | 1A-9 QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Wind River | 36 | Lusk | 26 | 1A-9 QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Riverside | 8 | Pine Bluffs | 35 | 1A-9 QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Southeast | 22 | Rocky Mountain | 37 | 1A-9 QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Dubois | 56 | Hulett | 49 | 1A-6 QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Guernsey-Sunrise | 0 | Encampment | 68 | 1A-6 QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Kaycee | 8 | Snake River | 62 | 1A-6 QF | WHSAA |
| 2021 | Friday, October 29, 2021 | Meeteetse | 60 | Midwest | 0 | 1A-6 QF | WHSAA |
| 2021 | Friday, November 5, 2021 | Natrona | 24 | Sheridan | 38 | 4A SF | WHSAA |
| 2021 | Friday, November 5, 2021 | Cheyenne East | 34 | Rock Springs | 55 | 4A SF | WHSAA |
| 2021 | Friday, November 5, 2021 | Jackson | 28 | Douglas | 20 | 3A SF | WHSAA |
| 2021 | Friday, November 5, 2021 | Star Valley | 17 | Cody | 24 | 3A SF | WHSAA |
| 2021 | Friday, November 5, 2021 | Wheatland | 28 | Lyman | 38 | 2A SF | WHSAA |
| 2021 | Friday, November 5, 2021 | Lovell | 35 | Torrington | 7 | 2A SF | WHSAA |
| 2021 | Friday, November 5, 2021 | Wind River | 0 | Shoshoni | 27 | 1A-9 SF | WHSAA |
| 2021 | Friday, November 5, 2021 | Rocky Mountain | 30 | Pine Bluffs | 24 | 1A-9 SF | WHSAA |
| 2021 | Friday, November 5, 2021 | Dubois | 36 | Encampment | 56 | 1A-6 SF | WHSAA |
| 2021 | Friday, November 5, 2021 | Meeteetse | 46 | Snake River | 47 | 1A-6 SF | WHSAA |
| 2021 | Friday, November 12, 2021 | Encampment | 24 | Snake River | 65 | 1A-6 Championship-at Laramie | WHSAA |
| 2021 | Friday, November 12, 2021 | Jackson | 24 | Cody | 41 | 3A Championship-at Laramie | WHSAA |
| 2021 | Saturday, November 13, 2021 | Lovell | 6 | Lyman | 8 | 2A Championship-at Laramie | WHSAA |
| 2021 | Saturday, November 13, 2021 | Rocky Mountain | 6 | Shoshoni | 19 | 1A-9 Championship-at Laramie | WHSAA |
| 2021 | Saturday, November 13, 2021 | Rock Springs | 27 | Sheridan | 45 | 4A Championship-at Laramie | WHSAA |
| Season | Date | Away Team | Away Score | Home Team | Home Score | Notes | Source |