Say hi to: Basin, Cody, Cowley, Douglas, Evanston, Campbell County, Greybull, Powell, Thermopolis, Torrington, Worland.
Say bye-bye to: University Prep.
| Season | Date | Away Team | Away Score | Home Team | Home Score | Notes | Source |
|---|---|---|---|---|---|---|---|
| 1921 | Saturday, September 24, 1921 | Eaton (CO) | 14 | Cheyenne Central | 7 | CDT/WST | |
| 1921 | Friday, September 30, 1921 | Cowley | 6 | Basin | 12 | CDT/WST | |
| 1921 | Friday, September 30, 1921 | Worland | 14 | Greybull | 10 | CDT/WST | |
| 1921 | Friday, September 30, 1921 | Sidney (NE) | Cheyenne Central | canceled | WST | ||
| 1921 | Friday, September 30, 1921 | Edgemont (SD) | 33 | Newcastle | 21 | NNL | |
| 1921 | Friday, September 30, 1921 | Laramie | 52 | University Prep | 0 | LDB/LREP | |
| 1921 | Thursday, October 6, 1921 | Laramie | 0 | UW frosh | 27 | LREP | |
| 1921 | Friday, October 7, 1921 | Greybull | 19 | Thermopolis | 7 | CDT/TI | |
| 1921 | Friday, October 7, 1921 | Basin | 0 | Worland | 31 | CDT/WG | |
| 1921 | Friday, October 7, 1921 | Bayard (NE) | 39 | Torrington | 18 | TT | |
| 1921 | Saturday, October 8, 1921 | Douglas | 7 | Cheyenne Central | 127 | CDT | |
| 1921 | Saturday, October 8, 1921 | Newcastle | 0 | Sheridan | 57 | SPO | |
| 1921 | Saturday, October 8, 1921 | Campbell County | 0 | Buffalo | 87 | SPO | |
| 1921 | Wednesday, October 12, 1921 | Worland | 19 | Thermopolis | 32 | CDT/WST/TI | |
| 1921 | Friday, October 14, 1921 | Natrona | 60 | Douglas | 0 | CDT | |
| 1921 | Friday, October 14, 1921 | Campbell County | 12 | Newcastle | 84 | GN/NNL | |
| 1921 | Saturday, October 15, 1921 | Cheyenne Central | 0 | Laramie | 3 | WST | |
| 1921 | Saturday, October 15, 1921 | Cowley | 0 | Sheridan | 28 | SPO | |
| 1921 | Saturday, October 15, 1921 | Scottsbluff (NE) | 63 | Torrington | 0 | TT/GCJ | |
| 1921 | Friday, October 21, 1921 | Newcastle | 0 | Edgemont (SD) | 28 | NNL/NJ | |
| 1921 | Friday, October 21, 1921 | Thermopolis | 21 | Basin | 35 | CDT/TI | |
| 1921 | Friday, October 21, 1921 | Greybull | 14 | Cowley | 21 | CDT | |
| 1921 | Friday, October 21, 1921 | Torrington | 7 | Douglas | 7 | tie-disputed score | CDT/DE/TT/GCN |
| 1921 | Saturday, October 22, 1921 | Worland | 6 | Natrona | 82 | CDT | |
| 1921 | Saturday, October 22, 1921 | University Prep | 0 | Cheyenne Central | 6 | CDT | |
| 1921 | Saturday, October 22, 1921 | Billings (MT) | 6 | Sheridan | 21 | WST/SPO | |
| 1921 | Saturday, October 22, 1921 | Westminster College JV (UT) | 0 | Evanston | 14 | WYT | |
| 1921 | Saturday, October 22, 1921 | Buffalo | 51 | Campbell County | 6 | GN | |
| 1921 | Tuesday, October 25, 1921 | Basin | 87 | Cody | 0 | CDT | |
| 1921 | Friday, October 28, 1921 | Basin | 21 | Greybull | 71 | CDT/WST | |
| 1921 | Friday, October 28, 1921 | University Prep | 13 | Douglas | 0 | CDT | |
| 1921 | Friday, October 28, 1921 | Worland | 7 | Cowley | 27 | CDT/TI | |
| 1921 | Friday, October 28, 1921 | Cheyenne Central | Kimball (NE) | canceled | WST | ||
| 1921 | Friday, October 28, 1921 | Newcastle | 47 | Campbell County | 0 | GN | |
| 1921 | Friday, October 28, 1921 | Torrington | 0 | Morrill (NE) | 88 | TT | |
| 1921 | Saturday, October 29, 1921 | University Prep | 0 | Natrona | 54 | CDT | |
| 1921 | Saturday, October 29, 1921 | Fort Collins (CO) | 20 | Laramie | 13 | WST/LDB | |
| 1921 | Saturday, October 29, 1921 | Buffalo | 0 | Sheridan | 58 | WST | |
| 1921 | Saturday, October 29, 1921 | Thermopolis | 0 | Billings Poly (MT) | 82 | WG/TI | |
| 1921 | Friday, November 4, 1921 | Cody | 0 | Basin | 112 | CDT/BHCR | |
| 1921 | Friday, November 4, 1921 | Cowley | 27 | Thermopolis | 0 | CDT/TI | |
| 1921 | Friday, November 4, 1921 | Greybull | 13 | Worland | 34 | CDT/TI | |
| 1921 | Friday, November 4, 1921 | Newcastle | 0 | Edgemont (SD) | 52 | NNL | |
| 1921 | Friday, November 4, 1921 | Douglas | Bridgeport (NE) | canceled | DE/DB | ||
| 1921 | Friday, November 4, 1921 | Gering (NE) | 54 | Torrington | 0 | TT | |
| 1921 | Saturday, November 5, 1921 | Laramie | 9 | Cheyenne Central | 0 | CDT | |
| 1921 | Saturday, November 5, 1921 | Sheridan JV | 20 | Buffalo | 0 | SPO | |
| 1921 | Saturday, November 5, 1921 | Worden (MT) | 0 | Sheridan | 75 | SPO | |
| 1921 | Saturday, November 5, 1921 | Park City (UT) | 33 | Evanston | 13 | WYT | |
| 1921 | Friday, November 11, 1921 | Basin | 0 | Cowley | 69 | at Lovell | CDT |
| 1921 | Friday, November 11, 1921 | Thermopolis | 7 | Worland | 109 | CDT | |
| 1921 | Friday, November 11, 1921 | Sheridan | 7 | Natrona | 0 | CDT | |
| 1921 | Friday, November 11, 1921 | Cheyenne Central | 0 | Colorado Springs (CO) | 45 | CDT/WST | |
| 1921 | Friday, November 11, 1921 | Granite JV (UT) | 19 | Evanston | 6 | WYT | |
| 1921 | Friday, November 11, 1921 | Powell | 38 | Cody | 7 | CDT/PCE | |
| 1921 | Friday, November 11, 1921 | Newcastle | 26 | Buffalo | 7 | BB/NNL | |
| 1921 | Friday, November 11, 1921 | Douglas | 0 | Torrington | 37 | DE/TT | |
| 1921 | Friday, November 11, 1921 | Colorado State Frosh (CO) | 6 | Laramie | 36 | LREP | |
| 1921 | Wednesday, November 16, 1921 | Powell | 7 | Cowley | 21 | PT | |
| 1921 | Friday, November 18, 1921 | Basin | 33 | Thermopolis | 29 | CDT/TI/BHCR | |
| 1921 | Friday, November 18, 1921 | Cowley | 7 | Greybull | 7 | tie | CDT |
| 1921 | Saturday, November 19, 1921 | Natrona | 20 | Cheyenne Central | 31 | CDT | |
| 1921 | Saturday, November 19, 1921 | Sheridan | Miles City (MT) | canceled | SE | ||
| 1921 | Saturday, November 19, 1921 | Cowley | Powell | not played | PT | ||
| 1921 | Thursday, November 24, 1921 | Cowley | 40 | Worland | 20 | CDT | |
| 1921 | Thursday, November 24, 1921 | Greybull | 45 | Basin | 14 | CDT | |
| 1921 | Thursday, November 24, 1921 | Douglas | 6 | Natrona | 53 | CDT | |
| 1921 | Thursday, November 24, 1921 | Laramie | 0 | Sheridan | 20 | WST/LDB | |
| 1921 | Thursday, November 24, 1921 | Cody | 0 | Powell | 74 | PCE/PT | |
| 1921 | Friday, December 2, 1921 | Morrill (NE) | Torrington | canceled-snow | TT | ||
| Season | Date | Away Team | Away Score | Home Team | Home Score | Notes | Source |